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HUNTINGTON'S DISEASE
WHAT
IS IT?
A dominant genetic disorder in which a protein is produced
abnormally, leading to the breakdown in the parts of the brain that
control movement. A genetic disorder of the nervous system, characterised by
involuntary movement and progressive mental deterioration. A genetic disease of the central nervous system, that
produces progressive dementia and involuntary movements. It usually
starts between ages 30 and 50 and slowly progresses to death. Since it
is a dominant disease, a child of a parent with Huntington’s disease has
a 50-50 chance of inheriting it.
An adult onset disease characterised by progress mental and
physical deterioration; it is caused by an inherited dominant gene mutation. A late but variable age onset lethal human disease of nerve
degeneration. Inherited as an autosomal dominant phenotype.
Shows imprinting individuals inheriting HD from their father shows significantly earlier
onset than those inheriting a maternal allele.
Shows genetic anticipation, in that the severity increase and
age of onset decreases in affected individuals of later generations in a
pedigree. The HD gene, encoding a protein called huntingtin, has been
cloned. A hereditary, progressive, neuro-degenerative disorder primarily
characterized by the development of emotional, behavioural, and
psychiatric abnormalities; gradual deterioration of the thought processing and acquired
intellectual ability-(dementia) and movement abnormalities; including
involuntary, rapid irregular jerky movement (chorea) of the face, arms,
legs or trunk. An inherited sex-linked nervous disease that develops in
adulthood and leads to a state of the deteriorated mentality. A fatal
neurological disease that begins after age 35 and leads to loss of motor
control and intellectual deterioration.
It is an hereditary disease of the brain characterised by the
onset in adult life of unusual body movements and mental deterioration.
the disease is chronically progressive.
Huntington’s chorea: hereditary disease is chronically progressive.
Huntington’s disease or Huntington’s chorea is an inherited
disorder characterized by abnormal body movement called chorea and loss
of memory. There also is evidence that doctors as far back as the middle
ages knew of this devastating disease. The incidence is 5 to 8 per 100,000.
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